一、个人信息
姓名：李先强
技术职务：讲师
学位：理学博士
研究领域：药学、药剂学、药理学
Email: lixq@ahstu.edu.cn 或 lixianqiang89@sina.com
办公电话：13855036421
二、个人简介
安徽科技学院A类人才引进，主要从事植物源细胞外囊泡作为亚单位疫苗佐剂的开发与应用研究。相关研究成果发表在Clinical immunology，Langmuir，Food and Chemical Toxicology等期刊上。获得国家自然科学基金，安徽省高等学校科学研究重大项目等资助。
三、教育经历
2021.12-2023.01，长三角药物高等研究院，药剂学专业，博士。
2020.09-2023.06，沈阳药科大学，药剂学专业，博士。
2012.09-2015.07，华中农业大学，药理学专业，硕士。
2008.09-2012.07，安徽科技学院，动物医学专业，学士。
四、工作经历
2023.06-至今，安徽科技学院，生物医学与健康学院，讲师
2015.08-2020.08，塔里木大学，动物科学技术学院，讲师
五、主持课题
1. 安徽省教育厅重大项目，2024AH040059，基于薄荷外泌体高效上调病毒亚单位疫苗免疫原性的研究，2024.05-2027.05
2. 安徽科技学院人才启动项目，负载植物外泌体纳米凝胶增效mRNA树突状细胞肿瘤疫苗的研究，2023.11-2031.10
3. 校企产学研-山海异兽生命科学（佛山）有限公司，881412，外泌体纳米囊泡免疫抗病毒技术的研发与应用，2023.12-2025.12
4. 校企产学研-山海异兽生命科学（佛山）有限公司，881773，薄荷外泌体偶联亚单位疫苗抗原技术的研发与应用，2023.12-2025.12
5. 国家自然科学基金项目，31660729，氟苯尼考对猪链球菌的药动学-药效学同步模型研究，2017.01-2020.12
6. 塔里木大学人才启动项目，TDZKQN201603，氟苯尼考包合物微球纳米混悬剂的研制，2016.01-2018.12
7. 新疆生产建设兵团2018年科技特派员专项资金项目. BT1720180068G. 2018.09-2019.12
8. 新疆生产建设兵团2017年科技特派员专项资金项目. BT1720170003G. 2017.09-2018.12
六、代表性论文
1. Xianqiang Li, Jinhuan Liu, Jinfeng Dou, Chao Li, Yongtao Jiang, Ali Dawood, Jie Wei, Yurong Wei, Youyi Xiong, Wanhe Luo, Samah Algharib. Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum-Gelatin Composite Nanogels, Langmuir, 2024, 40(9): 4860-4870
2. Xianqiang Li, Yue Wu, Sixue Wang, Jun Liu, Tingting Zhang, Yimei Wei, Lili Zhu, Wei Bai, Tiantian Ye*, Shujun Wang*. Menthol nanoliposomes enhanced anti-tumor immunotherapy by increasing lymph node homing of dendritic cell vaccines. Clinical immunology.2022,224:109119.
3. Xianqiang Li, Yue Wu, Rui Zhang, Wei Bai, Tiantian Ye*, Shujun Wang*. Oxygen-based nanocarriers to modulate tumor hypoxia for ameliorated anti-tumor therapy: fabrications, properties, and future directions. Frontiers in Molecular Biosciences. 2021, 8:683519.
4. Jiamao Chen#, Ting Yang#, Jimin Long, Yanhuai Ding, Juan Li, Xianqiang Li*, Yi Cao*. Palmitate enhanced the cytotoxicity of ZnO nanomaterials possibly by promoting endoplasmic reticulum stress. Journal of Applied Toxicology.2019, 39(5):798-806.
5. Xuqi Zhao#, Shiwei Chang#, Jimin Long, Juan Li, Xianqiang Li*, Yi Cao*. The toxicity of multi-walled carbon nanotubes (MWCNTs) to human endothelial cells: The influence of diameters of MWCNTs. Food and Chemical Toxicology. 2019. 126: 169-177.
6. Xianqiang Li, Yuanfang Tang, Chunying Chen, Dexin Qiu*, Yi Cao*. PEGylated Au nanorods are not cytotoxic to human endothelial cells but affect Kruppel-like factor signaling pathway. Toxicology and applied pharmacology. 2019,382(11):114758.
7. Jimin Long#, Xianqiang Li#, Yang Kang, Yanhuai Ding*, Zhipeng Gu*, Yi Cao. Internalization, cytotoxicity, oxidative stress and inflammation of multi-walled carbon nanotubes in human endothelial cells: influence of preincubation with bovine serum albumin, RSC Advances, 2018, 8:9253-9260.
8. Yu Gong#, Xianqiang Li#, Guochao Liao, Yanhuai Ding*, Juan Li*, Yi Cao. Cytotoxicity and ER stress-apoptosis gene expression in ZnO nanoparticle exposed THP-1 macrophages: influence of pre-incubation with BSA or palmitic acids complexed to BSA. RSC Advances. 2018, 8, 15380-15388.
9. Ling Zhang, Yonghong Liu, Junfeng Liu, Li Zhao, Xianqiang Li*. Tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, 2018, 41(2):307-313.
10. Yanping Wang, Ling Zhang, Saeed Ahmed, Yonghong Liu, Xianqiang Li*. Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics. Arquivo Brasileiro De Medicina Veterinaria E Zootecni, 2018,70(5):1497-1504.
11. Xianqiang Li*, Xin Fang, Yanhuai Ding, Juan Li*, Yi Cao. Toxicity of ZnO nanoparticles (NPs) with or without hydrophobic surface coating to THP-1 macrophages: interactions with BSA or oleate-BSA. Toxicology Mechanisms and Methods. 2018, 28:7, 520-528.
12. Ling Zhang#, Youwen Li#, Yanping Wang, Abdul Sajid, Saeed Ahmed, Xianqiang Li*. Integration of pharmacokinetic-pharmacodynamic for dose optimization of doxycycline against Haemophilus parasuis in pigs. Journal of Veterinary Pharmacology and Therapeutics. 2018,41(5): 706-718.
13. Ling Zhang#, Li Zhao#, Yonghong Liu, Junfeng Liu, Xianqiang Li*. Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis. Journal of Veterinary Science. 2017,18(4):431-437.
14. Ling Zhang, Yonghong Liu, Changqing Shi, Junfeng Liu, Li Zhao, Chunyu Jiang, Xianqiang Li*. Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles. Journal of Veterinary Pharmacology and Therapeutic. 2017,40(3):293-303.
15. Xianqiang Li#, Shuyu Xie#, Yuanhu Pan, Wei Qu, Yanfei Tao, Dongmei Chen, Lingli Huang, Zhenli Liu, Yulian Wang*, Zonghui Yuan*, Preparation, characterization and pharmacokinetics of doxycycline hydrochloride and florfenicol polyvinylpyrrolidone microparticle entrapped with hydroxypropyl-β-cyclodextrin inclusion complexes suspension, Colloids and Surfaces B: Biointerfaces, 2016, 141: 634-642.